Serotonin & Melatonin Pathway Report FAQ
What is the Serotonin & Melatonin Pathway Report?
The Serotonin & Melatonin Pathway Report analyzes your genetic variants along a key neurochemical axis that influences mood, sleep, digestion, and circadian rhythm. By examining how your body converts tryptophan into serotonin and then into melatonin, the report helps uncover potential genetic bottlenecks and underlying causes of common health issues.
This functional report is especially useful for individuals dealing with mood imbalances, anxiety, depression, sleep disruptions, appetite issues, stress sensitivity, or metabolic symptoms related to circadian misalignment.
Why this pathway matters
Serotonin and melatonin are critical signaling molecules:
- Serotonin plays a role in mood stability, motivation, digestion, and stress response.
- Melatonin regulates sleep onset and circadian rhythm.
- Genetic differences in this pathway can affect synthesis, receptor activity, transport, and rhythm control, contributing to issues with mood, energy, sleep, and metabolic processes.
How does this report work?
This report maps the biological steps from tryptophan intake to serotonin and melatonin production, and it identifies where genetic variants may alter efficiency or create “bottlenecks.” It evaluates:
- Serotonin synthesis and signaling
- Melatonin production and circadian release
- Receptor and transporter function
- Clock genes that influence daily rhythms
Which genes are included?
Key genes evaluated in this report include:
- TPH2 – serotonin synthesis
- SLC6A4 – serotonin transporter
- ASMT – enzyme in melatonin synthesis
- MTNR1B – melatonin receptor
- CLOCK – circadian rhythm regulator
…and additional related genes.
Each gene is analyzed to show how your variants may affect the pathway steps and overall balance between serotonin and melatonin.
What will I learn from this report?
The report provides insights into:
- How your genes influence serotonin production and signaling
- Genetic effects on melatonin synthesis and circadian rhythm
- Differences in neurotransmitter balance that might impact mood or sleep
- Potential functional bottlenecks that could be underlying symptoms
- Connections between this pathway and digestion, stress response, and metabolic resilience
These insights can help you or your practitioner tailor lifestyle, nutrition, and supplement strategies to support better mood regulation and sleep health.
Who may benefit from this report?
This report is ideal for anyone with:
- Persistent sleep issues or circadian disruption
- Mood instability, anxiety, or low stress resilience
- Appetite or digestion irregularities
- Trouble with daily energy, motivation, or recovery
- Interest in deeper functional insights into mood and sleep biology
How is this different from other reports?
Unlike general health reports, the Serotonin & Melatonin Pathway Report focuses on functional biology — it looks at how your genes interact within a specific neurochemical system rather than isolated variants. This provides a more integrated view of how your genetic makeup affects key physiological processes.