Histamine Pathway Report
What is the Histamine Pathway Report?
The Histamine Pathway Report shows how your genes may affect your body’s ability to produce, break down, and regulate histamine.
Histamine is a natural compound involved in many key processes:
- Immune response (allergies, inflammation)
- Digestion (stomach acid production)
- Sleep–wake cycle and alertness
- Neurotransmitter signaling
If histamine levels get too high, it can lead to symptoms like headaches, skin issues, digestive discomfort, congestion, or feeling “wired.” Your genes help control how efficiently histamine is cleared from the body, and this report explains where you may have strengths or vulnerabilities.
How to Read Your Report
1. Results Overview
You’ll see a summary of your genetic results, showing whether you may have:
- Typical histamine processing
- Reduced histamine breakdown (risk of higher histamine)
- Changes in genes that affect histamine receptors or transport
2. Gene–SNP Breakdown
The detailed section lists each gene in the histamine pathway, your genotype (from your DNA kit), and how that result may influence histamine balance.
- Blockers: Things that may reduce enzyme efficiency (e.g., alcohol, certain medications, nutrient deficiencies).
- Enhancers: Nutrients and lifestyle supports that can help regulate histamine (e.g., vitamin C, DAO enzyme support, quercetin, low-histamine diet).
3. Recommendations
Your report provides personalized suggestions based on your DNA, including:
- Dietary adjustments (foods naturally lower in histamine, or those that support DAO activity).
- Supplements that may help (vitamin C, B vitamins, quercetin, probiotics).
- Lifestyle practices to reduce histamine load (stress reduction, managing allergies, avoiding alcohol).
4. Lab Markers to Check
The report may suggest markers like plasma histamine or DAO activity to help you and your practitioner get real-world insight into how your body is handling histamine.
FAQs
Q: What genes are included in the Histamine Pathway Report?
The report covers major genes involved in histamine production, breakdown, and transport — such as DAO, HNMT, MAOA, and histamine receptor genes.
Q: If my report shows reduced histamine breakdown, does that mean I’m intolerant?
Not necessarily. Your genes only show predispositions. Lifestyle, diet, environment, and gut health all play a big role in histamine levels.
Q: Why do some reports say “not determined”?
That means your DNA file did not include certain SNPs for that gene. It doesn’t change the overall accuracy of your report.
Q: Can my histamine genes change over time?
No — your genes don’t change. But how they function can be influenced by diet, environment, and lifestyle choices (epigenetics). That means you can take action to support your histamine balance.