Do You Accept Whole Genome Sequencing (WGS) Files?

Yes! SelfDecode accepts Whole Genome Sequencing (WGS) files from select providers, as long as they meet the following requirements:

• Must be Whole Genome Sequencing (WGS) — we do not accept Whole Exome Sequencing (WES) files
• Must be 10x coverage or higher (30x is the industry standard and recommended)
• VCF files: Must be gzip compressed (.vcf.gz). Uncompressed VCF files (which can be 4GB+) are not supported. Most providers offer gzip compressed downloads by default.
• TXT files: Can be uploaded as .zip compressed files.

Supported WGS Providers

We generally support WGS data from:

• Dante Labs (30x)
• Nebula Genomics (30x or 100x)

If you tested with one of these providers, you can upload your file directly to SelfDecode. Visit the Upload Your DNA File page to get started.

Uploading a third-party file gives you access to features equivalent to the Essential Bundle.

Important: If your provider offers multiple coverage options, make sure your test was at least 10x coverage. Low-pass sequencing (1x or 3x) does not provide sufficient data quality for our platform.

Tested With Another WGS Provider?

If your WGS data comes from a different company, we may still be able to help. Compatibility depends on how the file was generated and formatted.

Please email support@selfdecode.com with:

• The name of the testing provider
• The coverage depth of your test (e.g., 10x, 30x)
• The file type you received (VCF, compressed VCF, etc.)

Our team will review it and let you know whether it can be uploaded successfully.

Get the Full Experience With SelfDecode Whole Genome Sequencing

SelfDecode now offers its own 30x Whole Genome Sequencing (WGS) — designed to work seamlessly with our platform and unlock the most complete experience possible.

Why Choose SelfDecode WGS?

• Maximum Genetic Coverage — Our 30x WGS reads 100% of your genome (over 3 billion base pairs) directly, not through estimation or imputation. This is the highest-resolution genetic testing available to consumers.
• Access to Exclusive Reports & Features — Unlock WGS-only reports including the ACMG SF v3.3 Clinical Predisposition Report, Advanced Pharmacogenomics (800+ medications), and Ultimate Rare Variant Screening — none of which are available with third-party uploads.
• Optimized Accuracy — Our lab and algorithms are designed to work together, ensuring the highest level of accuracy and consistency across all your reports.
• Future-Proof Your Data — Your genome only needs to be sequenced once. As new research and reports are released, your existing WGS data powers them automatically — no retesting needed.
• Simple At-Home Collection — A painless cheek swab you can do in under 2 minutes. No blood draw, no clinic visit. Just swab, mail it back with the prepaid label, and we handle the rest.
• HSA/FSA Eligible — All SelfDecode WGS packages qualify for HSA and FSA spending.

Packages start at $749. Learn more and get started here.

Need Help Understanding Your Results?

DecodyGPT (also called Decody) is your personal AI health coach — available to answer questions about your reports and help you explore personalized health insights based on your genetic data.

Learn more about how to use DecodyGPT to get the most from your results.