Allele Inheritance

Everyone has two alleles at each variant — you inherit one from your mother and one from your father. Together they make up your genotype at that spot in your DNA.

The major and minor alleles combine in one of three ways in each person. Geneticists call these genotypes:

  • Homozygous major — two copies of the major allele
  • Homozygous minor — two copies of the minor allele
  • Heterozygous — one copy of each

For example, the two alleles of the BDNF gene are the major 'C' and the minor 'T'. The possible genotype combinations are:

  • 'CC' (homozygous major)
  • 'CT' (heterozygous)
  • 'TT' (homozygous minor)

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