PromicsEdge - Whole Genome Sequencing (WGS) for Practitioners

Whole Genome Sequencing (WGS) is available on PromicsEdge. Order it for new clients or as an upgrade for existing ones directly from your practitioner account. WGS reads all 3 billion base pairs of a client's genome directly, so it detects rare and structural variants that standard genotyping cannot.

Standard Genotyping vs. WGS

Standard genotyping analyzes approximately 0.1% of the genome and uses imputation to enrich the sample. It covers the vast majority of common health variants and performs well for population-level risk scoring and lifestyle-based recommendations. Imputation is a prediction by definition — it cannot detect rare variants or resolve structural changes in the genome.

WGS reads all 3 billion base pairs directly and completely, with no inference. This is a fundamentally different level of resolution, not an incremental upgrade, and it is based on Illumina Next-Generation Sequencing (NGS).

What's Included

• 30x Whole Genome Sequencing (raw data only) — The sequencing itself. Every base pair of the client's DNA is read an average of 30 times, generating a complete, permanent genomic dataset in standard VCF/BAM formats. This is the foundation all WGS reports are built on. Once sequenced, the client never needs to retest — new reports can be generated from the same dataset as science advances.
• Whole Genome Genius Report — A full WGS analysis identifying the most clinically relevant genetic variants, metabolic pathways, pharmacogenomic insights, and disease-risk signals across the entire genome. Translates complex genomics into actionable strategies for health optimization, longevity, precision medicine, and preventive care.
• Ultimate Rare Variant Screening — Identifies rare variants that are actually disrupting the client's biology, including variants conventional reports miss. Focuses on which rare variants have significant impact and what can be done about them, rather than surfacing a raw list of findings without context.
• ACMG SF v3.3 Report — Screens for serious, medically actionable genetic risks based on the American College of Medical Genetics and Genomics Secondary Findings v3.3 guidelines. Covers inherited cancer, cardiovascular, and metabolic conditions — findings used to guide real medical decisions, not wellness insights. View a sample report.
• Advanced Pharmacogenomics (PGx) Report — Maps the client's personal drug-response profile across hundreds of medications and supplements, using full genome data to accurately resolve complex structural variants in drug metabolism genes (e.g., CYP2D6) that standard genotyping routinely misses.
• HLA & Antigen Report (coming soon) — Reads HLA genes directly from the whole genome at full four-digit resolution. Crucial for estimating the risk of autoimmune and inflammatory conditions such as celiac disease, ankylosing spondylitis, narcolepsy, and rheumatoid arthritis. Also maps the complete antigen profile: HLA typing for transplant compatibility, blood group typing, and platelet antigen typing.

Several report tiers are available for clients. For current pricing, see Professional Checkout and Pricing or contact support@promicsedge.com.

Curious how our WGS compares with others? See the scientific and technical details that set it apart.

Where WGS Adds the Most Clinical Value

When a rare variant exists in a client's genome, standard genotyping often won't find it — not because it failed, but because it wasn't designed to look there. WGS has no blind spots. Key clinical areas where WGS stands out:

• Hereditary Cancer Risk — Full gene sequencing detects rare and novel variants in BRCA1/2, TP53, Lynch syndrome genes, and others that genotyping panels routinely miss.
• Pharmacogenomics — Accurately resolves complex structural variants in drug metabolism genes (e.g., CYP2D6) that are critical for safe medication dosing.
• Rare Variant Detection — The only method that reliably identifies low-frequency variants with outsized health impact.
• Cardiovascular & Inherited Cardiac Conditions — Identifies rare variants associated with cardiomyopathies, arrhythmia syndromes, and familial hypercholesterolemia.
• Neurological & Neurodegenerative Risk — Full coverage of genes such as LRRK2 and PSEN1/2, relevant to Alzheimer's, Parkinson's, and epilepsy.
• Structural Variants & CNVs — Detects large genomic rearrangements (deletions, duplications, inversions) implicated in cancer, immune dysfunction, and developmental conditions.

When to Recommend WGS

Not every client needs WGS. Consider it for clients who:

• Have complex, unresolved presentations where standard genetic insights haven't provided a clear answer
• Have a personal or family history of rare genetic conditions, hereditary cancers, or atypical drug responses
• Are pursuing a longevity or precision medicine program and want the most complete genetic foundation available
• Have already completed standard testing and want to go deeper
• Want the highest possible confidence that nothing has been missed

For these clients, WGS is the right clinical starting point, not an optional add-on.

How to Order WGS

Upgrading an Existing Client

1. Log in to your PromicsEdge account.
2. Open the client profile you want to upgrade.
3. Click More > Whole Genome in the top menu.

Note: Existing clients with our original genetic test done in the United States don't need a new kit. The system recognizes this and assigns the correct product at checkout.

Ordering WGS for a New Client

1. From your main dashboard, click Add Client.
2. Select any individual WGS reports or entire bundles (Premium or WGS).
3. Complete the checkout

Pricing

See the this article for detailed WGS pricing.

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