PromicsEdge - Whole Genome Sequencing (WGS) for Practitioners

Whole Genome Sequencing (WGS) is now available on PromicsEdge! You can order it for new clients or as an upgrade for existing ones directly from your practitioner account.

Standard Genotyping vs. WGS

Our standard DNA test analyzes approximately 0.1% of the genome and uses imputation to enrich the sample. This covers the vast majority of common health variants and performs well for population-level risk scoring and lifestyle-based recommendations.

Imputation is by definition a prediction — it cannot detect rare variants or resolve structural changes in the genome.

🔬WGS reads all 3 billion base pairs directly and completely, with no inference. This is a fundamentally different level of resolution, not an incremental upgrade. It's based on Illumina Next-Generation Sequencing (NGS).

What's Included

• 30x Whole Genome Sequencing (raw data only) The sequencing itself. Every base pair of the client's DNA is read an average of 30 times, generating a complete, permanent genomic dataset in standard VCF/BAM formats. This is the foundation all WGS reports are built on. Once sequenced, the client never needs to retest — new reports can be generated from the same dataset as science advances.
• Whole Genome Genius Report A full WGS analysis that identifies the most clinically relevant genetic variants, metabolic pathways, pharmacogenomic insights, and disease-risk signals across the entire genome. Translates complex genomics into actionable strategies for health optimization, longevity, precision medicine, and preventive care.
• Ultimate Rare Variant Screening Identifies rare variants that are actually disrupting the client's biology — including variants that conventional reports miss. Focuses on which rare variants have significant impact and what can be done about them, rather than surfacing a raw list of findings without context.
• ACMG SF v3.3 Report Screens for serious, medically actionable genetic risks based on the American College of Medical Genetics and Genomics Secondary Findings v3.3 guidelines. Covers inherited cancer, cardiovascular, and metabolic conditions. These are findings used to guide real medical decisions, not wellness insights. Sample report available here.
• Advanced Pharmacogenomics (PGx) Report Maps the client's personal drug-response profile across hundreds of medications and supplements, using full genome data to accurately resolve complex structural variants in drug metabolism genes (e.g., CYP2D6) that standard genotyping routinely misses.

There are several report tiers available for clients. For current pricing, see Professional Checkout and Pricing or contact support@promicsedge.com.

Where WGS Adds the Most Clinical Value

When a rare variant exists in a client's genome, standard genotyping often won't find it — not because it failed, but because it wasn't designed to look there. WGS has no blind spots. Key clinical areas where WGS stands out:

• Hereditary Cancer Risk — Full gene sequencing detects rare and novel variants in BRCA1/2, TP53, Lynch syndrome genes, and others that genotyping panels routinely miss.
• Pharmacogenomics — Accurately resolves complex structural variants in drug metabolism genes (e.g., CYP2D6) that are critical for safe medication dosing.
• Rare Variant Detection — The only method that reliably identifies low-frequency variants with outsized health impact.
• Cardiovascular & Inherited Cardiac Conditions — Identifies rare variants associated with cardiomyopathies, arrhythmia syndromes, and familial hypercholesterolemia.
• Neurological & Neurodegenerative Risk — Full coverage of genes such as LRRK2 and PSEN1/2, relevant to Alzheimer's, Parkinson's, and epilepsy.
• Structural Variants & CNVs — Detects large genomic rearrangements (deletions, duplications, inversions) implicated in cancer, immune dysfunction, and developmental conditions.

When to Recommend WGS

Not every client needs WGS. Consider it for clients who:

• Have complex, unresolved presentations where standard genetic insights haven't provided a clear answer
• Have a personal or family history of rare genetic conditions, hereditary cancers, or atypical drug responses
• Are pursuing a longevity or precision medicine program and want the most complete genetic foundation available
• Have already completed standard testing and want to go deeper
• Want the highest possible confidence that nothing has been missed

For these clients, WGS is the right clinical starting point, not an optional add-on.

How to Order WGS

Upgrading an Existing Client

1. Log in to your PromicsEdge account.
2. Open the client profile you want to upgrade.
3. Click WGS in the top menu.

Note: Existing clients with our original genetic test done in the United States don't need a new kit. The system will recognize this and assign the correct product at checkout.

Ordering WGS for a New Client

WGS is not yet available in the standard new client checkout. Use the workaround below in the meantime.

1. From your main dashboard, click Add Client.
2. Select any standard reports or bundles you want alongside WGS-specific reports.

3. For the DNA kit option, do not select "Send a DNA Kit" — choose any other available option.

   

4. Follow steps 2–3 from the instructions for existing clients above to complete the WGS order.

WGS Pricing for Practitioners

Please refer to the practitioner pricing document for detailed WGS pricing.